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1084 UNUSUAL LABORATORY FINDINGS IN ECHOVIRUS-11 MENINGITIS
Abstract   Open access   Peer reviewed

1084 UNUSUAL LABORATORY FINDINGS IN ECHOVIRUS-11 MENINGITIS

C Hurry Thompson, Margaret C Fisher, Adamadia Deforest, Sarah S Long and Angelo M DiGeorge
Pediatric research, v 15(Suppl 4), pp 623-623
01 Jan 1981
DOI: https://doi.org/10.1203/00006450-198104001-01110
url
https://www.nature.com/articles/pr19811422.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1203/00006450-198104001-01110View
Published, Version of Record (VoR) Open

Abstract

Echovirus 11(E-11) was isolated from the cerebrospinal fluid (CSF) of 22 children in a 1980 summer outbreak of meningitis. Seventeen(77%) were <6 mos old(range 2 wk-9 yr). 54% had CSF cell counts >300/mm 3 and 14% had >500/mm 3 (range 0-2250). 59% had ≥50% polymorphonuclears(P) and 24% had >90% P. None had CSF glucose <40mg/dl; 41% had CSF protein ≥45mg/dl and 6% had >75mg/dl. Three patients(pts) had entirely normal CSF. In 86% peripheral WBC was 5000-15000/mm 3 ; only 3 had >75% P but 20% had absolute band count >500/mm 3 Four pts(<3 mos old) had repeat CSF exams. All had >50 cells/mm 3 and the two youngest(age 2 wk) still had >50% P after 1 and 3 days. CSF findings were compared with data from pts with bacterial meningitis(B). Cell count >500/mm 3 , glucose ≤45mg/dl, and protein >75mg/dl were statistically associated with B. However, 14% of E-11 pts had at least one of these findings and 20% of B pts had none of these findings. CSF P >75% was as frequent in E-11 pts as in B pts. Peripheral WBC <5000 or >15000/mm 3 and absolute band count >500/mm 3 were statistically associated with B but 38% of E-ll pts had one of these abnormalities. Certain CSF findings in our pts have not been reported for E-11 and are uncharacteristic of viral meningitis: 1) leukocyte response more characteristic of bacterial meningitis: CSF P >90%, persistence of CSF P beyond 24 hrs, peripheral band count >500, and 2) entirely normal CSF.

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