Abstract
Abstract 18: Relation of Migraine to Stroke Risk in Postmenopausal Women: Findings from the Women’s Health Initiative
Stroke (1970), v 56(Suppl_1)
Feb 2025
Abstract
Abstract only Introduction: Migraines are a known risk factor for stroke among reproductive-aged women, though the relation of migraines to stroke risk among postmenopausal women remains unclear. We assessed the association between a history of diagnosed migraine and incident stroke among postmenopausal women and investigated age differences in the association. Methods: We included women enrolled in the Women’s Health Initiative (WHI), a large longitudinal cohort study of postmenopausal women in the U.S. We excluded women with a history of stroke or TIA at baseline or with missing data on history of migraine or key covariates. The primary exposure was a history at baseline of self-reported migraine diagnosed by a physician. The primary outcome was incident stroke (total, ischemic [IS], or hemorrhagic [ICH]). Multivariable Cox proportional hazards models were used to test the cause-specific hazard ratios (HRs) between migraine history and total stroke, IS (overall and by subtype), and ICH, sequentially adjusted for age and traditional and female-specific risk factors. Using multivariable Cox proportional hazard models, we then quantified the association between migraine history and total stroke by age in 5-year groups at baseline. Results: 130,277 participants were included. The median age at baseline was 61 years (IQR 56-67 years) for those with a migraine history compared to 63 years (IQR 57-69 years) for those without. Overall, 5,743 strokes occurred over a median follow-up period of 19.9 years (IQR 9.1-25). In multivariable-adjusted models (Table), there was a marginal association between migraine history and total stroke (HR=1.07; 95% CI, 0.99-1.17) and a significant association between migraine history and IS (HR=1.12; 95% CI, 1.02-1.23), most pronounced in the cardioembolic category. Migraine was not associated with risk of ICH (HR=0.85, 95%CI, 0.67-1.09). Risk appears to be of greatest magnitude in early (HR 1.26, 95% 0.93-1.72) and late (HR 1.16, 95%CI 0.89-1.50) postmenopausal years (Figure), though the differences by age group were not statistically significant. Conclusions: Over a 20-year follow-up period, postmenopausal women with self-reported histories of migraine had a higher risk of IS, but not total or ICH, suggesting that migraine history contributes to ischemic stroke risk during the postmenopausal years. Along with other known risk factors, migraine history should be considered in stroke risk factor screening and prevention efforts after menopause.
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Details
- Title
- Abstract 18: Relation of Migraine to Stroke Risk in Postmenopausal Women: Findings from the Women’s Health Initiative
- Creators
- Tracy Madsen - Brown UniversityChristina Raker - Rhode Island HospitalJelena Pavlovic - Montefiore Medical CenterMatthew Allison - University of California, San DiegoLaura Harrington - Kaiser PermanenteBernard Haring - Sarrland University, Homburg, GermanyFarha Ikramuddin - University of Minnesota Medical CenterLongjian Liu - Drexel UniversitySimin Liu - Brown UniversityJoAnn Manson - Brigham and Women's HospitalDon Penzien - Wake Forest, Winston Salem, North Carolina, United StatesNazmus Saquib - Stanford UniversityPETER Schnatz - Reading HospitalAladdin Shadyab - University of California, San DiegoMarcia Stefanick - Palo Alto UniversityJean Wactawski-Wende - University at Buffalo, State University of New YorkRobert Wild - University of Oklahoma Health Sciences CenterBrian Silver - University of Massachusetts Chan Medical School
- Publication Details
- Stroke (1970), v 56(Suppl_1)
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
- Number of pages
- 2
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001435578700018
- Other Identifier
- 991022026257204721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease