Abstract
An Alternative Immune Cell Labeling System Based on the New Two-Dimensional Nanomaterials MXenes
The Journal of immunology (1950), v 212(1_Supplement), 268_5819
01 May 2024
Abstract
Abstract Deepening our understanding of immune cell behavior is vital for creating safe, effective treatments, particularly as immune cell therapy, also known as cellular immunotherapy or cell-based immunotherapy, represents a groundbreaking approach in the treatment of various diseases, including cancer. Transition metal carbides and nitrides (MXenes), a novel family of 2D nanomaterials, show promise as advanced trackers for immune cells—key for precise diagnostics and therapies. Traditional cell labeling methods have stagnated due to limited chemical options, impeding progress in applied medicine. Moreover, these methods are incompatible with single-cell mass cytometry by time-of-flight (CyTOF), a globally adopted technology that improves classical flow cytometry. We propose an innovative solution utilizing MXenes to overcome these challenges. Our method, Label-free sINgle-cell tracKing of 2D matErials by mass cytometry (LINKED), leverages a novel, biocompatible, multiplexed, label-free detection approach via CyTOF and Mass Ion Beam Imaging by Time-of-Flight (MIBI-TOF). This technique overcomes chemical limitations and integrates seamlessly with CyTOF, allowing for nanomaterial detection and simultaneous measurement of diverse immune cell and tissue features. Our work promises to advance immunological research significantly, offering refined cell labeling and tracking techniques crucial for the advancement of translational medicine.
Metrics
2 Record Views
Details
- Title
- An Alternative Immune Cell Labeling System Based on the New Two-Dimensional Nanomaterials MXenes
- Creators
- Linda Giro - University of PaduaLaura Fusco - University of PaduaArianna Gazzi - University of PaduaChacon BenjaminChristopher Shuck - Drexel UniversityKlaus Ley - Augusta UniversityMarco Orecchioni - Augusta UniversityYury Gogotsi - Drexel UniversityLucia Delogu - Khalifa University of Science and Technology
- Publication Details
- The Journal of immunology (1950), v 212(1_Supplement), 268_5819
- Publisher
- American Association of Immunologists (AAI)
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Materials Science and Engineering; A.J. Drexel Nanomaterials Institute
- Other Identifier
- 991021959915104721