Abstract
Association of social environment with clinically meaningful declines in health-related quality of life domain bother and function in individuals after prostate cancer treatment
Journal of clinical oncology, v 44(16_suppl), e17025
01 Jun 2026
Abstract
e17025Background: Clinically meaningful (CM) changes in function and bother have a significant impact on health-related quality of life (HRQoL) after prostate cancer (PCa) treatment. The role of social environment in these changes is unclear. This study aims to examine the relationship between social environment and CM changes in HRQoL-related function and bother after PCa treatment. Methods: Deidentified patient data from CaPSURE registry were geocoded and linked with CDC Social Vulnerability Index (SVI) data, which ranks communities based on vulnerability to public health crises (high SVI: ≥75th percentile nationally). High SVI was defined as ≥75th percentile nationally. HRQoL (0-100 (best)) was assessed using the UCLA Prostate Cancer Index for urinary (UF and UB), sexual (SF and SB), and bowel (BF and BB) function and bother, at baseline and two years post-treatment. CM changes at two years were those > ½ standard deviation from mean baseline scores; changes in function or bother were deemed discordant. Multivariable logistic regressions assessed associations between SVI and discordant CM changes in HRQoL, adjusting for sociodemographics and treatment. Odds ratios (OR) and 95% confidence intervals (CI) were presented, p < 0.05 was significant. Results: Among 8,904 men, mean age at diagnosis was 65.36 years. The cohort was 86.5% White, 9.8% Black, and 3.7% Asian/Latino/Other. 22% had > 3 comorbidities [3-4 (18.3%), and ≥5 (3.9%)]. Discordant CM changes at two-years post treatment noted in 12.5% for urinary, 17.7% for sexual, and 9.5% for bowel domains. High-SVI patients had lower baseline HRQoL across all domains, for example, UF (89.03 vs 92.63), BF (85.08 vs 88.43), and SF (49.09 vs 53.81). Compared with radical prostatectomy, other treatment modalities were associated with higher odds of urinary and sexual function decline and increased bowel bother. High SVI was linked with lower odds of discordant CM change in sexual domain (OR 0.35, 95% CI 0.16-0.73), but not in urinary or bowel domains. Conclusions: High SVI is associated with worse baseline HRQoL scores and lower odds of discordant, clinically meaningful declines in sexual HRQoL, meaning greater risk of concurrent declines in both sexual function and bother. Linking patients from high SVI communities undergoing PCa treatment with more resources and support may improve HRQoL and survivorship.
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Details
- Title
- Association of social environment with clinically meaningful declines in health-related quality of life domain bother and function in individuals after prostate cancer treatment
- Creators
- Disha Srivastava - Drexel UniversityAngad Jhandi - Eastern Virginia Medical SchoolTyler Cain - Bryan CollegeNonna Shakhnazaryan - University of California, San FranciscoZachary Boston - Rutgers, The State University of New JerseyLufan Wang - University of California, San FranciscoJanet E. Cowan - University of California, San FranciscoJune M. Chan - University of California, San FranciscoSalma Shariff-Marco - University of California, San FranciscoPeter Carroll - University of California, San FranciscoSamuel L. Washington - University of California, San Francisco
- Publication Details
- Journal of clinical oncology, v 44(16_suppl), e17025
- Publisher
- American Society of Clinical Oncology
- Number of pages
- 138
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001780599300001
- Other Identifier
- 991022195747504721