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Brain-Integrated Psychiatry: Neuroimaging-aided Comprehensive Cognitive Assessment towards informed Diagnosis and Treatment in Schizophrenia
Abstract   Open access

Brain-Integrated Psychiatry: Neuroimaging-aided Comprehensive Cognitive Assessment towards informed Diagnosis and Treatment in Schizophrenia

Adrian Curtin, Junfeng Sun, Qiangfeng Zhao, Banu Onaral, Jijun Wang, Shanbao Tong and Hasan Ayaz
Frontiers in human neuroscience, v 12
2018
url
https://doi.org/10.3389/conf.fnhum.2018.227.00081View
Published, Version of Record (VoR) Open CC BY V4.0

Abstract

A critical issue in modern psychiatry is the lack of objective biomarkers which grant insight into patient status and diagnosis. In particular, in Schizophrenia, a severe and disabling mental disorder characterized by deficits in cognitive processes, perception, and emotional responsiveness, both clinical diagnosis and status are evaluated only using behavioral measures or subjective self-reports of patients. The high degree of heterogeneity in patients with Schizophrenia presents a particular challenge to physicians as the manifest symptoms and best therapeutic approach are with high individual variability (Lehman, Lieberman, & Dixon, 2010). Treatment-resistant patients, who do not respond successfully to initial treatments, may be discouraged from attempting further strategies and jeopardize future medication adherence(Liu-Seifert, Adams, & Kinon, 2005). Therefore, there is a distinct clinical need for technologies which can be used to quickly optimize current pharmacological therapies as well as evaluate the impact of developing conjunctive approaches such as cognitive behavioral therapy and neurostimulation.

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