Abstract
Evaluating Outcomes of Mother-Infant Pairs Using Dolutegravir for Treatment of HIV During Pregnancy
Open forum infectious diseases, v 4(suppl_1), pp S665-S666
04 Oct 2017
Abstract
Abstract
Background
Dolutegravir (DTG) is a highly efficacious and well tolerated antiretroviral (ART) for the treatment of HIV infection. Although on the preferred treatment list for people living with HIV, it is not a treatment option for pregnant women because data on efficacy, tolerability during pregnancy, and teratogenicity are limited.
Methods
We performed a descriptive cohort analysis of pregnant women from the Drexel Women’s Care Center (WCC) receiving DTG for HIV treatment during pregnancy. The Drexel WCC reports maternal and fetal outcomes to the Antiretroviral Pregnancy Registry, a national de-identified database of pregnant women with HIV on ART. Here, we evaluate maternal and fetal outcomes of mother-infant pairs with DTG use during pregnancy between 2015 and 2017.
Results
During the study period, 19 pregnant women used DTG for HIV treatment; 14 had live deliveries and 5 were still pregnant at the time of abstract submission. DTG use was five times higher in 2017 compared with 2015 (Figure 1). All deliveries resulted in live fetuses with negative HIV status, although there was one fetus from a twin pregnancy with a congenital abnormality. The majority of women were diagnosed with HIV before pregnancy (84%), were already on DTG when entering pregnancy (63%) and remained on the same regimen until labor and delivery (Table 1).
Conclusion
We found that DTG use is increasing among a clinic cohort of pregnant women with HIV with signs of treatment tolerability during pregnancy. The risk of teratogenicity will need to be fully assessed as more clinics report fetal outcomes among infants exposed to DTG.
Disclosures
All authors: No reported disclosures.
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Details
- Title
- Evaluating Outcomes of Mother-Infant Pairs Using Dolutegravir for Treatment of HIV During Pregnancy
- Creators
- Kedesha Sibliss - Drexel UniversityOlivia Kirby - Drexel UniversityHervette Nkwihoreze - Drexel UniversityErika Aaron - Drexel UniversityGregg Alleyne - Drexel UniversityFlorence Momplaisir - Drexel University
- Publication Details
- Open forum infectious diseases, v 4(suppl_1), pp S665-S666
- Publisher
- Oxford University Press
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Other Identifier
- 991021910533504721