Abstract
Feasibility of dietary intervention in a breast cancer population
Journal of clinical oncology, v 30(15_suppl), e11505
20 May 2012
Abstract
Abstract only
e11505
Background: Caloric restriction (CR), or reducing caloric intake by 20-40%, induces molecular changes which are also altered in breast cancer leaving cancer cells more susceptible to cytotoxic treatment. In vivo, CR decreases tumor growth and metastases. Recent research shows that breast cancer patients with metabolic syndrome and high blood glucose had higher mortality and poorer response to treatment. Diet modification may be an attractive potential adjunct to improve standard therapies, but little is known of the feasibility of enrolling patients into such a trial. Methods: After obtaining IRB approval, a survey was administered to a sample of patients in an academic breast cancer clinic to determine their interest in participating in nutrition trials during cancer treatment. Women were questioned regarding demographics, overall health status, comorbidities, and willingness to participate in clinical trials aimed at potentially increasing the efficacy of treatment through diet. Results: 50 breast cancer patients participated. 48% had comorbidities, 56% were self or physician-described as overweight, and 76% exercise at least once per week. 70% of respondents state that nutrition was never discussed with a physician prior to cancer care, 32% searched online for dietary information, and 62% expressed willingness to participate in a clinical trial involving a dietary regimen. Patients willing to participate in such a trial were more likely to be: currently exercising (73%), vitamin users (90%), not obese (64%), and more educated about diet related information (78%). Patients determined the most important tools to help them with dietary trial compliance would be speaking with a dietician weekly and weekly phone calls with the physician. Adherence would be increased if participants were provided meals. Conclusions: A significant proportion of breast cancer patients in this survey are interested in nutritional guidance and there is strong interest in participating in clinical trials with a dietary modification. Promising approaches include weekly meetings with dieticians and phone-based support. Based on these data, clinical trials of nutritional interventions appear warranted and feasible for enrolling breast cancer patients.
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Details
- Title
- Feasibility of dietary intervention in a breast cancer population
- Creators
- Colin E. Champ - Thomas Jefferson University HospitalPramila R. Anne - Thomas Jefferson UniversityTimothy Norman Showalter - Thomas Jefferson UniversityMila J Heersink - Thomas Jefferson University HospitalRosanne Iacono - Thomas Jefferson University HospitalMark Vikas Mishra - Sidney Kimmel Cancer CenterAdam P. Dicker - Thomas Jefferson University HospitalAnne Louise Rosenberg - Thomas Jefferson University HospitalNicole L. Simone - Thomas Jefferson University Hospital
- Publication Details
- Journal of clinical oncology, v 30(15_suppl), e11505
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Other Identifier
- 991021897387504721