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Abstract
Fluoride Exposure and Concurrent Cognitive Outcomes in 7-15 Year Old Children from Mexico City, Mexico
Environmental health perspectives. Supplements, v 2020(1)
26 Oct 2020
Abstract
BACKGROUND: Recent studies have reported an inverse association between fluoride exposure and IQ in children, but most were ecological in design. Few involved personal measures of exposure or adjusted for confounders.
METHODS: This study utilized archived urine samples and data from offspring who participated in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) pregnancy and birth cohort project to study concurrent fluoride exposure and its association with cognitive outcomes in 565 children ages 7-15 years old. Generalized Additive Models (GAM) were used to test the association between specific gravity-adjusted urinary fluoride levels and total score from the Wechsler Abbreviated Scale of Intelligence (WASI), adjusting for child’s sex, child’s age, gestational age, birth weight, birth order, maternal intelligence score, maternal age, maternal education, marital status, maternal education, maternal smoking history, family possessions, and cohort. GAM were also re-run after stratifying by sex (NMales = 298, NFemales = 267).
RESULTS: Concurrent urinary fluoride was not significantly associated with WASI scores in children, and sex did not modify the association.
CONCLUSIONS: The results of this cross-sectional study do not support the hypothesis that concurrent fluoride exposure has an impact on cognitive function among children aged 7-15 years.
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Details
- Title
- Fluoride Exposure and Concurrent Cognitive Outcomes in 7-15 Year Old Children from Mexico City, Mexico
- Creators
- D. B. Thomas - Cornell UniversityY. Lin - Brown UniversityK. Peterson - University of MichiganB. N. Sanchez - Drexel UniversityN. Basu - McGill UniversityE. Martinez-Mier - University of IndianapolisA. Mercado-Garcia - National Institute Of Technology SilcharL. Schnaas - National Institute Of Technology SilcharC. Till - York UniversityM. Hernandez-Avila - National Institute Of Technology SilcharH. Hu - University of WashingtonM. Tellez-Rojo - National Institute Of Technology Silchar
- Publication Details
- Environmental health perspectives. Supplements, v 2020(1)
- Conference
- ISEE 2020 Virtual Conference: 32nd Annual Conference of the International Society of Environmental Epidemiology (Virtual, 24 Aug 2020–27 Aug 2020)
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Other Identifier
- 991020111253904721