Abstract
Impact of a ketogenic diet intervention during radiotherapy on body composition: III-final results of the KETOCOMP study for breast cancer patients
Breast cancer research : BCR, v 22(1), pp 94-94
20 Aug 2020
PMID: 32819413
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Obesity and low muscle mass are associated with worse outcomes of breast cancer patients. We conducted a controlled trial to study the impact of a ketogenic diet (KD) based on natural foods versus an unspecified standard diet (SD) on body composition in breast cancer patients undergoing radiotherapy.
Methods: Patients with non-metastasized breast cancer were allocated to either the KD (N = 32) or the SD (N = 31) during radiotherapy. Body composition was measured weekly by bioimpedance analysis. Blood parameters and quality of life were assessed before, during, and at the end of radiotherapy.
Results: A total of 29 KD and 30 SD patients completed the study. During radiotherapy, mean and median fasting BHB concentrations in the KD group were 0.72 and 0.49 mmol/l (range 0.06-4.9) which was significantly higher than those in the SD group (p < 2.2 x 10(-16)). There was a very small and insignificant increase in body weight and fat mass in the SD group, as well as a decrease of fat free mass. In contrast, patients in the KD group lost body weight and fat free and skeletal muscle mass quickly after diet onset, which for the most part was related to water losses. The KD did not cause further substantial changes in fat free or skeletal muscle mass, but was associated with a gradual decrease of 0.4 kg body weight and fat mass per week (p < 0.0001). The KD significantly decreased free T3 levels by 0.06 pg/ml/week (p = 6.3 x 10(-5)). Global quality of life remained stable in the SD group but increased in the KD group from a score of 66.7 to 75.0 (p = 0.20).
Conclusions: In breast cancer patients undergoing curative radiotherapy, a KD based on natural foods is feasible. After initial water losses, the KD tends to reduce body weight and fat mass while preserving fat free and skeletal muscle mass.
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Details
- Title
- Impact of a ketogenic diet intervention during radiotherapy on body composition: III-final results of the KETOCOMP study for breast cancer patients
- Creators
- Rainer J. Klement - Leopoldina Krankenhaus SchweinfurtColin E. Champ - Duke Medical CenterUlrike Kaemmerer - Univ Hosp Wurzburg, Dept Obstet & Gynaecol, Wurzburg, GermanyPetra S. Koebrunner - Leopoldina Krankenhaus SchweinfurtKelley Krage - Leopoldina Krankenhaus SchweinfurtGabriele Schaefer - Leopoldina Hosp, Dept Radiat Oncol, Robert Koch Str 10, D-97422 Schweinfurt, GermanyM. Weigel - Leopoldina Krankenhaus SchweinfurtReinhart A. Sweeney - Leopoldina Krankenhaus Schweinfurt
- Publication Details
- Breast cancer research : BCR, v 22(1), pp 94-94
- Publisher
- Springer Nature
- Number of pages
- 14
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000567186400002
- Scopus ID
- 2-s2.0-85089768970
- Other Identifier
- 991021897277604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology