Abstract
Independent and Joint Associations of Obesity, Physical Activity, and Galectin-3: The Atherosclerosis Risk in Communities Study (ARIC)
Circulation (New York, N.Y.), v 138(Suppl 1), pp A10970-A10970
06 Nov 2018
Abstract
Background
Obesity and low physical activity (PA) are interrelated risk factors for heart failure (HF) via incompletely understood mechanisms. Galectin-3 (gal-3) is a marker of inflammation and fibrosis that is associated with increased HF risk.HypothesisWe hypothesized that obesity and low PA would be associated with increased odds of elevated gal-3.
Methods
We evaluated 8,750 ARIC participants (mean age 63 years; 21% black; 58% women) who were free of CVD at Visit 4 (1996-98). Body mass index (BMI) was assessed at Visit 4. Exercise PA was assessed at Visit 3 (1993-95) using a modified Baecke questionnaire and categorized per AHA guidelines (recommended, intermediate, and poor). Gal-3 was measured from Visit 4 serum samples, with values >90 percentile being defined as elevated. In cross-sectional analyses, we used adjusted logistic regression models to estimate the independent and combined associations of obesity and PA with elevated gal-3. We also assessed the prospective association of gal-3 with HF within cross-categories of obesity status and PA.
Results
Compared to normal weight, higher BMI was associated with higher odds of elevated gal-3 (OR 2.02; 95% CI 1.52, 2.69 for severely obese vs normal weight). Lower PA was also associated with higher odds of elevated gal-3 (OR 1.43; 95% CI 1.18, 1.74 for poor vs recommended). In analyses using cross-categories of obesity and PA, compared to normal weight persons with recommended PA, those with obesity and poor PA had the highest odds of elevated gal-3 (Table). There was no significant interaction between obesity and PA on the outcome of elevated gal-3 (p = 0.70). In prospective analyses, elevated gal-3 was similarly associated with increased HF risk among all obesity and PA subgroups (p for interaction of gal-3 with cross-categories = 0.48).
Conclusion
Obesity and lower PA category were associated with a higher likelihood of elevated gal-3. Obesity and low PA may be associated with inflammation and fibrosis, which are important pathways leading to HF.
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Details
- Title
- Independent and Joint Associations of Obesity, Physical Activity, and Galectin-3: The Atherosclerosis Risk in Communities Study (ARIC)
- Creators
- Roberta Florido - Johns Hopkins UniversityVijay Nambi - Michael E. DeBakey VA Medical CenterLucia Kwak - Johns Hopkins UniversityRon Hoogeveen - Baylor College of MedicineMariana Lazo - Johns Hopkins UniversityGary Gerstenblith - Johns Hopkins UniversityRoger Blumenthal - Johns Hopkins UniversityJosef Coresh - Johns Hopkins UniversityAaron Folsom - University of MinnesotaElizabeth Selvin - Johns Hopkins UniversityChristie Ballantyne - Baylor College of MedicineChiadi Ndumele - Johns Hopkins University
- Publication Details
- Circulation (New York, N.Y.), v 138(Suppl 1), pp A10970-A10970
- Conference
- American Heart Association's 2018 Scientific Sessions (Chicago, Illinois, United States, 10 Nov 2018–12 Nov 2018)
- Publisher
- American College of Cardiology Foundation and the American Heart Association, Inc
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Urban Health Collaborative; Community Health and Prevention
- Other Identifier
- 991020550497804721