Abstract
The elevated serum Monocyte Chemoattractant Protein‐1 (MCP‐1) in obesity is influenced by parathyroid hormone (PTH) and not body mass index (BMI)
The FASEB journal, v 24(S1), pp 935.7-935.7
Apr 2010
Abstract
Monocyte chemoattractant protein‐1 is an inflammatory cytokine that is produced predominantly by macrophages, endothelial cells and is expressed in adipose tissue, and also by the mature osteoblast. PTH administration increases gene expression and serum MCP‐1 in rodents, yet both MCP‐1 and PTH are elevated in obesity. The goal in this study was to determine whether the higher MCP‐1 in obesity is influenced by PTH. We recruited 84 women aged 51 ± 10 years, who were either normal‐weight (NL‐wt, n = 38, BMI = 22 ± 2 kg/m2) or obese (Ob, n = 46, BMI = 44 ± 7 kg/m2) and further separated them into 2 categories based on median of PTH. BMI, fat mass, lean mass and calcium intake did not differ in the two PTH groups in NL‐wt and Ob women. PTH was inversely associated with serum 25 hydroxy vitamin D levels in the entire population (r = −0.31, p<0.01). Ob and NL‐wt women in the high PTH groups had higher MCP‐1 (p<0.05) and no difference in control adipokines [C‐reactive protein (CRP) and adiponectin]. As expected, CRP was higher and adiponectin was lower (p<0.05) in Ob than NL‐wt women, whereas MCP‐1 did not differ due to weight category. We found that the positive association between MCP‐1 and BMI was only present when PTH was <40 pg/mL (normal = 10–55 pg/mL). Together, these data suggest that when serum PTH is in the high‐normal range, it has a greater influence on MCP‐1 than BMI, as observed in both NL‐wt and Ob women.
Grant Funding Source: CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCES (CCTS)‐ UMDNJ
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Details
- Title
- The elevated serum Monocyte Chemoattractant Protein‐1 (MCP‐1) in obesity is influenced by parathyroid hormone (PTH) and not body mass index (BMI)
- Creators
- DEEPTHA Sukumar - Rutgers, The State University of New JerseyNICOLA Partridge - New York UniversityXIANGBING Wang - University of Medicine and Dentistry of New JerseySUE Shapses - Rutgers, The State University of New Jersey
- Publication Details
- The FASEB journal, v 24(S1), pp 935.7-935.7
- Publisher
- Federation of American Societies for Experimental Biology
- Number of pages
- 1
- Grant note
- CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCES (CCTS)‐ UMDNJ
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Nutrition Sciences
- Other Identifier
- 991019231625904721