Abstract
Triangulation to make decisions about what are modifiable risk factors and the new risk factors
Alzheimer's & dementia, v 20(S4)
Dec 2024
PMID: 39782324
Abstract
Background
The 2020 Lancet Commission on dementia prevention, intervention and care estimated that up to 40% of dementia cases could be prevented by tackling 12 potentially modifiable risk factors, namely less education, hearing loss, hypertension, physical inactivity, diabetes, social isolation, excessive alcohol consumption, air pollution, smoking, obesity, traumatic brain injury, depression. As more evidence on risk factors emerges, the Lancet standing commission on dementia met to update evidence on established dementia risk factors and to consider the evidence for other risk factors.
Method
We used a lifecourse approach to understand how to reduce risk or prevent dementia, as many risks operate at different timepoints in the lifespan. We considered evidence for when in the lifecourse a risk factor was relevant to development of dementia as well as the size of the effect and strength of the evidence. Our interdisciplinary, international, multicultural group of experts adopted a triangulation framework, prioritising systematic reviews and meta‐analyses, performing new meta‐analyses where needed and debated and agreed on the best available evidence and its consistency. We considered whether there was evidence of disparities in impact of risk factors based on demographic characteristics, particularly ethnicity and socioeconomic status.
Result
Evidence for two new risk factors was considered strong enough to include this in our lifecourse model. We will present evidence for incorporation of these risk factors, including strength of evidence and potential mechanisms. We will also discuss risk factors for which evidence was not strong enough.
Conclusion
As more evidence about risk factors emerges we can increase our understanding of how dementia develops and how to potentially prevent it. Understanding the landscape of dementia prevention research is also helpful to appreciate where further evidence is needed and what form of evidence would be most helpful in advancing our understanding.
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Details
- Title
- Triangulation to make decisions about what are modifiable risk factors and the new risk factors
- Creators
- Naaheed Mukadam - University College LondonGill Livingston - University College LondonJonathan D Huntley - University of ExeterKathy Y Liu - University College LondonSergi Costafreda Gonzalez - University College LondonGeir Selbaek - Norwegian National Center for Ageing and Health, Vestfold Hospital Trust, TønsbergSuvarna Alladi - National Institute of Mental Health and NeurosciencesDavid Ames - National Ageing Research InstituteSube Banerjee - University of NottinghamAlistair Burns - University of ManchesterCarol Brayne - University of CambridgeNick C Fox - University College LondonCleusa P Ferri - Universidade Federal de São PauloLaura N. Gitlin - Drexel UniversityRobert J Howard - University College LondonHelen C Kales - University of California, DavisMika Kivimaki - University College LondonEric B Larson - University of WashingtonNoeline Nakasujja - Makerere UniversityKenneth Rockwood - Dalhousie UniversityQuincy M Samus - Johns Hopkins UniversityKokoro Shirai - The University of OsakaArchana Singh-Manoux - University College LondonLon S. S. Schneider - Keck Hospital of USCSebastian Walsh - Cambridge University Health PartnersYao Yao - Peking UniversityAndrew Sommerlad - University College London
- Publication Details
- Alzheimer's & dementia, v 20(S4)
- Publisher
- Wiley
- Number of pages
- 2
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- College of Nursing and Health Professions
- Other Identifier
- 991022018707304721