Abstract
Using patient-reported outcomes to assess the impact of germline genetic testing on prostate cancer patients
Journal of clinical oncology, v 41(16_suppl), 10607
01 Jun 2023
Abstract
10607
Background: Germline genetic testing (GGT) affords prostate cancer (PCa) patients (pts) opportunities for targeted therapies, prevention and cascade testing. Patient-reported outcomes (PRO) can evaluate physician effectiveness in promoting patient test comprehension and clinical decision making, which are critical to realize the benefits of GGT. PROs from a large PCa GGT study among urologists were analyzed. Methods: A prospective study enrolled unselected PCa pts from 15 primarily community urology practices. Pts underwent 84-gene GGT, with PROs collected via electronic or paper surveys >1-month post GGT. Differences in proportions were determined using two-tailed Fisher’s exact test and significance was set at <0.05. Results: PROs were completed by 561/982 (57%) pts (85% white, 82% non-metastatic, median age at testing 70 years). 59 (11%) pts had positive results, 247 (44%) negative and 255 (46%) variants of uncertain significance (VUS). 72% accurately recalled their result (range, 50% [VUS]-93% [negative]). 66% of positive pts, 80% negative and 54% VUS correctly understood if their result was associated with cancer risk or not. 72% of positive pts had or planned to complete ≥1 physician recommendations, significantly more than negative or VUS pts (Table). Most pts reported that their test result reduced their concerns (40%) or did not impact their level of concern (52%) regarding their PCa diagnosis, treatment or followup. 19% of positive pts reported increased concern. Conclusions: GGT for PCa was deployed without causing undue concern and resulted in adherence to physician recommendations. Still, there is room for improvement in how test results (especially VUS) and recommendations are communicated to pts. [Table: see text]
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Details
- Title
- Using patient-reported outcomes to assess the impact of germline genetic testing on prostate cancer patients
- Creators
- Sarah M. Nielsen - InvitaeNeal D. Shore - Carolina Urologic Research CenterMukaram Gazi - Urology AssociatesChristopher Michael Pieczonka - SUNY Upstate Medical UniversitySean Heron - AUI Health—Advanced Urology Institute, St Petersburg, FLDavid J Cahn - Colorado Urology, Golden, COLaurence Belkoff - Midlantic Urology, Bala Cynwyd, PAAaron D. Berger - Associated Urological Specialists, Chicago Ridge, ILBrian Mazzarella - Urology Austin, Austin, TXJoseph Veys - Georgia UrologyDavid Morris - Urology AssociatesRichard Bevan-Thomas - Urology Partners, Arlington, TXAlexander Engelman - Tampa General HospitalPaul Dato - HealthPartnersRobert Cornell - DermSurgery AssociatesDavid R Wise - NYU Langone HealthMary Kay Hardwick - Targeted Medical PharmaBrandie Heald - InvitaeRobert Luke Nussbaum - InvitaeEdward D. Esplin - Invitae
- Publication Details
- Journal of clinical oncology, v 41(16_suppl), 10607
- Resource Type
- Abstract
- Language
- English
- Academic Unit
- Surgery
- Other Identifier
- 991021916909304721