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Annotation
Effect of guselkumab on serum biomarkers in patients with active psoriatic arthritis and inadequate response to tumor necrosis factor inhibitors: results from the COSMOS phase 3b study (vol 25, 150, 2023)
Arthritis research & therapy, v 25(1), 170
15 Sep 2023
PMID: 37715280
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Following publication of the original article [1], the authors reported that the corrections were not carried out during the revisions.
The corrections are provided below and the changes have been set in bold typeface.
Author details:
1 Department of Medicine 3 – Rheumatology and Immunology, Universitatsklinikum Erlangen, Erlangen, Germany.
Abstract
Methods
Adults with active PsA (≥ 3 swollen joints, ≥ 3 tender joints) and IR to one or two TNFi (TNFi-IR) were randomized 2:1 to guselkumab at Weeks 0, 4, then every 8 weeks (Q8W) or placebo➔guselkumab Q8W at Week 24 with possible early escape at Week 16. Levels of serum cytokines, including interferon γ (IFNγ), IL-10, and tumor necrosis factor α (TNFα); T helper 17 (Th17) effector cytokines IL-17A, IL-17F, and IL-22; and acute phase proteins C-reactive protein (CRP), IL-6, and serum amyloid A (SAA), were assessed and compared with demographically matched healthy controls; guselkumab pharmacodynamics through Week 24 were also assessed.
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Details
- Title
- Effect of guselkumab on serum biomarkers in patients with active psoriatic arthritis and inadequate response to tumor necrosis factor inhibitors: results from the COSMOS phase 3b study (vol 25, 150, 2023)
- Creators
- Georg Schett (Corresponding Author) - Universitätsklinikum ErlangenWarner Chen - JanssenSheng Gao - JanssenSoumya D. Chakravarty - Drexel UniversityMay Shawi - Health AffairsFrederic Lavie - JanssenMiriam Zimmermann - JanssenMohamed Sharaf - Johnson & JohnsonLaura C. Coates - Nuffield Orthopaedic CentreStefan Siebert - University of Glasgow
- Publication Details
- Arthritis research & therapy, v 25(1), 170
- Publisher
- Springer Nature
- Number of pages
- 3
- Resource Type
- Annotation
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Web of Science ID
- WOS:001069842500003
- Scopus ID
- 2-s2.0-85171364288
- Other Identifier
- 991021930317004721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology