Book chapter
17 - Complement and systemic lupus erythematosus
Dubois' Lupus Erythematosus and Related Syndromes, pp 245-264
2025
Abstract
The complement system is arguably linked more intimately to SLE than to any other human disease. This association has been recognized for decades and was viewed as inexplicably paradoxical. Discoveries made during the past several years have begun to explain this perplexing link between complement and SLE and have concomitantly identified potential strategies and opportunities for mining the complement system for lupus genes, biomarkers, and therapeutics. In this chapter, we will review the biology of the complement system in relation to SLE, summarize common methods for measurement of complement, revisit the utility of complement assays in clinical management of SLE, and consider the potential for targeting the complement system for therapeutic intervention.
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Details
- Title
- 17 - Complement and systemic lupus erythematosus
- Creators
- Chau-Ching LiuSusan ManziJoseph M. Ahearn
- Publication Details
- Dubois' Lupus Erythematosus and Related Syndromes, pp 245-264
- Publisher
- Elsevier
- Edition
- Tenth Edition
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Scopus ID
- 2-s2.0-85198595666
- Other Identifier
- 991022084532004721