Book chapter
Anatomical, Biochemical, and Behavioral Evidence for Cannabinoid Modulation of Noradrenergic Circuits: Role of Norepinephrine in Cannabinoid-Induced Aversion
Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders, pp 135-156
08 Jul 2013
Abstract
The noradrenergic system plays a critical role in the modulation of emotional state, primarily related to anxiety, arousal, and stress. Recent evidence suggests that the endocannabinoid system mediates stress responses and emotional homeostasis, in part, by targeting noradrenergic circuits. This chapter summarizes our current knowledge regarding the anatomical substrates underlying regulation of noradrenergic circuitry by the endocannabinoid system. It then presents biochemical and functional evidence showing an important effect of cannabinoid modulation on adrenergic receptor signaling. Finally, the impact of this interaction with respect to specific behaviors is explored, demonstrating that norepinephrine is a critical determinant of cannabinoid-induced aversion, which adds another dimension to how central noradrenergic circuitry is regulated by the cannabinoid system.
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2 citations in Scopus
Details
- Title
- Anatomical, Biochemical, and Behavioral Evidence for Cannabinoid Modulation of Noradrenergic Circuits: Role of Norepinephrine in Cannabinoid-Induced Aversion
- Creators
- Ana Franky Carvalho - University of MinhoElisabeth J. Van Bockstaele - Jefferson Hospital for Neuroscience
- Contributors
- Elisabeth J. Van Bockstaele (Editor) - Jefferson Hospital for Neuroscience
- Publication Details
- Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders, pp 135-156
- Publisher
- Springer New York; New York, NY
- Number of pages
- 22
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Scopus ID
- 2-s2.0-84929579237
- Other Identifier
- 991021903412604721