Book chapter
Assessment of Apoptosis and Neuronal Loss in Animal Models of HIV-1-Associated Neurocognitive Disorders
Transmission Electron Microscopy Methods for Understanding the Brain, pp 217-243
23 Feb 2016
Abstract
HIV-1-associated neurocognitive disorder (HAND) is a neurodegenerative disease resulting in various clinical manifestations, characterized by neuroinflammation, oxidative stress, and related events. Neuronal damage in HAND is felt to be mainly indirect: microglial cells infected by HIV-1 increase the production of cytokines and release HIV-1 proteins, the most likely neurotoxins, among which are the envelope proteins gp120 and gp41 and the nonstructural proteins Nef, Rev, Vpr, and Tat. We review and discuss here different methods used in the assessment of apoptosis and neuronal loss in different experimental, acute and chronic, models of HAND. We also briefly consider how these techniques help to evaluate the effects of gene delivery of antioxidant enzymes in animal models of HAND.
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2 citations in Scopus
Details
- Title
- Assessment of Apoptosis and Neuronal Loss in Animal Models of HIV-1-Associated Neurocognitive Disorders
- Creators
- Jean-Pierre LouboutinBeverly ReyesLokesh Agrawal - Thomas Jefferson UniversityElisabeth Van Bockstaele - Drexel UniversityDavid S. Strayer - Thomas Jefferson University
- Contributors
- Elisabeth J. Van Bockstaele (Editor) - Drexel University
- Publication Details
- Transmission Electron Microscopy Methods for Understanding the Brain, pp 217-243
- Series
- Neuromethods
- Publisher
- Springer New York; New York, NY
- Number of pages
- 27
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Scopus ID
- 2-s2.0-84978218438
- Other Identifier
- 991021903124604721