Book chapter
Biochemical Basis of Hypoxic-Ischemic Encephalopathy
Neonatology, pp 1147-1159
01 Jan 2012
Abstract
Perinatal hypoxia ischemia is the most common cause of neurologic disease during the neonatal period. Hypoxic ischemic encephalopathy (HIE), is associated with a high mortality and morbidity rate, including cerebral palsy, mental retardation, and seizures [1]. The incidence of perinatal asphyxia is about 1.0–1.5% in most centers and is usually related to gestational age and birth weight. It occurs in 9.0% of infants less than 36 weeks’ gestation and in 0.5% of infants more than 36 weeks’ gestation [2, 3]. The etiology of perinatal HIE includes those circumstances that can affect the cerebral blood flow in the fetus and newborn compromising the supply of oxygen to the brain. They may develop antepartum (20%), intrapartum (30%), antepartum and intrapartum (35%), or postpartum (10%) [4].
Metrics
11 Record Views
Details
- Title
- Biochemical Basis of Hypoxic-Ischemic Encephalopathy
- Creators
- Maria Delivoria-Papadopoulos - Drexel UniversityEndla Anday
- Publication Details
- Neonatology, pp 1147-1159
- Publisher
- Springer Milan; Milano
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pediatrics
- Scopus ID
- 2-s2.0-84955392804
- Other Identifier
- 991019173700504721