Book chapter
Biomarker Enables Molecular Specific Optical Detection of Transplant Rejection
World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany, pp 740-743
2009
Abstract
Using serotonin as the biomarker, spatially re-solved Raman spectroscopy successfully detects heart transplant rejection without exogenous labeling and chemical fixation. The strong and characteristic Raman spectral signature of serotonin enables this direct optical detection without re-sorting to complicated data processing procedures. As the role of serotonin in various immune responses becomes increasingly recognized, this work presents a new paradigm in utilizing Raman spectroscopy as a clinically viable molecular specific diagnostic tool.
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Details
- Title
- Biomarker Enables Molecular Specific Optical Detection of Transplant Rejection
- Creators
- Qiang Tu - Drexel UniversityYoon Gi Chung - Drexel UniversityDianjun Cao - Drexel UniversityShuko Harada - Drexel UniversityChristine S. Cheng - University of California San DiegoHoward J Eisen - Drexel UniversityChang Chang - Drexel University
- Publication Details
- World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany, pp 740-743
- Conference
- World Congress on Medical Physics and Biomedical Engineering (Munich, Germany, 07 Sep 2009–12 Sep 2009)
- Series
- IFMBE Proceedings
- Publisher
- Springer Berlin Heidelberg; Berlin, Heidelberg
- Resource Type
- Book chapter
- Language
- English
- Scopus ID
- 2-s2.0-77949818184
- Other Identifier
- 991019335227804721