Book chapter
Biosensors
Resonant MEMS, pp 391-426
20 Apr 2015
Abstract
Biosensors based on resonant micro‐electromechanical systems (MEMS), sometimes called bioMEMS, are highly sensitive devices capable of label‐free quantitative measurement of biologics such as cells, viruses, proteins, and nucleic acids. This chapter is organized broadly as: design variation in resonant bioMEMS, techniques for sensor functionalization and target bio‐recognition, sensing measurement format, and application case studies. In the design section, considerations of sensor length scale, geometry, and fabrication materials are provided, each of which influence biosensor preparation and response characteristics. In the techniques section, common and effective surface functionalization techniques for various bio‐recognition agents, such as antibody and single‐strand DNA (ssDNA), are provided along with strategies for enhancing and verifying sensor response to target binding. In the measurement format section, batch versus continuous flow assay designs are discussed. In the applications section, several illustrative case studies of practical detection of biologics are highlighted in the chapter.
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Details
- Title
- Biosensors
- Creators
- Blake N Johnson - Drexel University, Department of Chemical and Biological Engineering, 3141 Chestnut Street, Philadelphia, PA 19104, USARaj Mutharasan - Drexel University
- Contributors
- Oliver Brand (Editor) - Georgia Institute of Technology, School of Electrical and Computer Engineering, 777 Atlantic Drive, Atlanta, GA 30332‐0250, USAIsabelle Dufour (Editor) - Université de Bordeaux, Laboratoire IMS, Bâtiment CBP, 16 av. Pey Berland, 33607 Pessac cedex, FranceStephen M Heinrich (Editor) - Marquette University, Department of Civil, Construction and Environmental Engineering, 265 Haggerty Hall, P.O. Box 1881, Milwaukee, WI 53201‐1881, USAFabien Josse (Editor) - Marquette University, Department of Electrical and Computer Engineering, 294 Haggerty Hall, P.O. Box 1881, Milwaukee, WI 53201‐1881, USA
- Publication Details
- Resonant MEMS, pp 391-426
- Publisher
- Wiley‐VCH Verlag GmbH & Co. KGaA; Weinheim, Germany
- Number of pages
- 36
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Scopus ID
- 2-s2.0-85027682030
- Other Identifier
- 991019173787704721