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Book chapter
Bone Metabolism in Obesity and Weight Loss
Annual review of nutrition, pp 287-309
01 Jan 2012
PMID: 22809104
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Excess body weight due to obesity has traditionally been considered to have a positive effect on bone; however, more recent findings suggest that bone quality is compromised. Both obesity and caloric restriction increase fracture risk and are regulated by endocrine factors and cytokines that have direct and indirect effects on bone and calcium absorption. Weight reduction will decrease bone mass and mineral density, but this varies by the individual's age, gender, and adiposity. Dietary modifications, exercise, and medications have been shown to attenuate the bone loss associated with weight reduction. Future obesity and weight loss trials would benefit from assessment of key hormones, adipokine and gut peptides that regulate calcium absorption, and bone mineral density and quality by using sensitive techniques in high-risk populations.
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Details
- Title
- Bone Metabolism in Obesity and Weight Loss
- Creators
- Sue A. Shapses - Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USADeeptha Sukumar - Rutgers, The State University of New Jersey
- Contributors
- R J Cousins (Editor)
- Publication Details
- Annual review of nutrition, pp 287-309
- Series
- Annual Review of Nutrition
- Publisher
- Annual Reviews; PALO ALTO
- Number of pages
- 23
- Grant note
- R01AG012161 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01 AG012161 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000307963100015
- Scopus ID
- 2-s2.0-84864267916
- Other Identifier
- 991019231645904721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Nutrition & Dietetics