Book chapter
Cancer Metabolism: Cross Talk Between Signaling and O-GlcNAcylation
Cancer Genomics and Proteomics
20 Jun 2014
PMID: 25030920
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cancer cells exhibit a unique metabolic shift to aerobic glycolysis that has been exploited diagnostically and therapeutically in the clinic. Oncogenes and tumor suppressors alter signaling pathways that lead to alterations of glycolytic flux. Stemming from glycolysis, the hexosamine biosynthetic pathway leads to elevated posttranslational addition of O-linked-β-N-acetylglucosamine (O-GlcNAc) on a diverse population of nuclear and cytosolic proteins, many of which regulate signaling pathways. This unit outlines techniques used to detect metabolic alterations in cancer cells, regulation by signaling pathways, and cellular O-GlcNAcylation.
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Details
- Title
- Cancer Metabolism: Cross Talk Between Signaling and O-GlcNAcylation
- Creators
- Christina M Ferrer - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, USAMauricio J Reginato - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, USA
- Publication Details
- Cancer Genomics and Proteomics
- Series
- Methods in Molecular Biology
- Publisher
- Springer New York; New York, NY
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000339721100008
- Scopus ID
- 2-s2.0-84958762084
- Other Identifier
- 991014877988704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology
- Genetics & Heredity
- Pathology