Book chapter
Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH‐AD Genetics Initiative
Alzheimer's Disease, pp 45-51
28 Mar 2001
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The complexity of Alzheimer's disease genetic research is illustrated by more than 20 genetic risk factors that have been reported for the late‐onset form of the disease in the literature to date. At present, only one risk factor, a common polymorphism in the apolipoprotein E gene, has been consistently found in several independent samples, using a variety of analytic methodologies. However, multiple lines of evidence indicate that there are additional genes involved in Alzheimer's disease. In fact, a recent study treating Alzheimer's disease as a quantitative trait estimated that at least four additional Alzheimer's disease genetic susceptibility loci exist beyond apolipoprotein E.
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Details
- Title
- Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH‐AD Genetics Initiative
- Creators
- Lars Bertram - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USADeborah Blacker - Gerontology Research Unit, Department of Psychiatry, MGH‐East, 149 13th Street, Charlestown, MA 02129, USAAdam S Crystal - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USAJennifer Jones - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USADevon Keeney - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USALaura MacKenzie-Ingano - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USAKristina Mullin - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USASanjay Basu - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USAStephen Yhu - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USAMelvin McInnis - Johns Hopkins UniversityRodney C. P Go - University of Alabama at BirminghamAleister J Saunders - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USARudolph E Tanzi - Genetics and Aging Unit, Department of Neurology, MGH‐East, 149 13th Street, Charlestown, MA 02129, USA
- Contributors
- Khalid Iqbal (Editor) - Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314‐6399, USASangram S Sisodia (Editor) - University of ChicagoBengt Winblad (Editor) - Karolinska Institute, NEUROTEC, Huddinge University Hospital, B 84, S‐141 86 Huddinge, Stockholm, Sweden
- Publication Details
- Alzheimer's Disease, pp 45-51
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 7
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000170986000005
- Other Identifier
- 991021463560704721
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- Web of Science research areas
- Clinical Neurology