Book chapter
Chapter 111 - Hepatitis B and Hepatitis D Viruses
Molecular Medical Microbiology, pp 2261-2279
2024
Abstract
Infection by hepatitis B virus (HBV) and hepatitis D virus (HDV) is a major health threat worldwide. In 2019 approximately 296 million individuals were living with a chronic HBV infection. Globally, a chronic HBV infection is the most common risk factor for developing hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality. HDV is a satellite virus of HBV and requires the HBV surface protein for genome packaging and transmission. Individuals with pre-existing chronic HBV infection who contract HDV, resulting in an HDV superinfection, have an increased risk of developing a chronic HBV/HDV infection, which greatly increases the risk of developing HCC compared to a chronic HBV infection. This chapter will describe the molecular biology, clinical features and pathogenesis, epidemiology, and methods to detect HBV and HDV. Infection-prevention strategies, current therapies, and mechanisms that could link a chronic HBV or HBV/HDV infection to HCC development will also be discussed.
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Details
- Title
- Chapter 111 - Hepatitis B and Hepatitis D Viruses
- Creators
- Andrea L. Rosenkranz - Drexel UniversityKyle C. Yeakle - Drexel UniversityMichael J. Bouchard - Drexel University
- Publication Details
- Molecular Medical Microbiology, pp 2261-2279
- Publisher
- Elsevier
- Edition
- Third Edition
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Scopus ID
- 2-s2.0-85184322624
- Other Identifier
- 991021852201004721