Book chapter
Chapter 19 - Lipid-based synthetic gene carriers
Nanostructures for Novel Therapy, pp 517-538
2017
Abstract
Gene therapy and gene silencing techniques are based on the insertion of nucleic acids (DNA or siRNA) into cells, with the goal of inducing therapeutic changes in cell functions. The need for carriers to facilitate this transfection process led to the study of lipid-nucleic acid assemblies, such as lipoplexes. The efficacy of lipoplexes is linked to their structure: the local, nanoscale structure of lipoplexes is an equilibrium feature, determined by lipid properties and complex composition. Larger-scale characteristics are, however, controlled by the assembly route and kinetics. This chapter reviews the equilibrium properties of lipoplexes and the kinetics pathways for their formation. Better understanding of lipoplex formation can not only lead to the design of effective nucleic acid lipoplex-based gene delivery or silencing agents, but is also of interest as a fundamental multicomponent, multilength-scale and multitime scale process.
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Details
- Title
- Chapter 19 - Lipid-based synthetic gene carriers
- Creators
- Nily Dan - Drexel University
- Publication Details
- Nanostructures for Novel Therapy, pp 517-538
- Publisher
- Elsevier
- Resource Type
- Book chapter
- Language
- English
- Scopus ID
- 2-s2.0-85027272064
- Other Identifier
- 991019312460904721