Book chapter
Chapter 22 - MicroRNA Regulation of mTOR Function
MicroRNA in Regenerative Medicine, pp 593-626
2023
Abstract
While most recognized for its role in cancer, the mammalian target of rapamycin (mTOR) pathway is emerging as an important mediator of nervous system regeneration and repair. miRNAs make up a class of regulatory molecules that exert posttranscriptional control over protein components of the mTOR signaling cascade. Using miRNA-mediated therapy to achieve precise control over mTOR activation may be one approach to normalizing the pathway in various disease states. As information about mTOR increases, research will center on how mTOR’s regulatory mechanisms go awry in pathological states such as cancer and neuro-degeneration. Elucidating these mechanisms is critical to understanding mTOR as a therapeutic target for overall human health and disease.
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Details
- Title
- Chapter 22 - MicroRNA Regulation of mTOR Function
- Creators
- Marina E. ZambrottaJohn D. Houlé
- Publication Details
- MicroRNA in Regenerative Medicine, pp 593-626
- Publisher
- Elsevier
- Edition
- Second Edition
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-85169387316
- Other Identifier
- 991020545124804721