Book chapter
Chapter 32 - Engineering Vascular Niche for Bone Tissue Regeneration
Biology and Engineering of Stem Cell Niches, pp 517-529
2017
Abstract
The use of autografts for bone repair is limited by donor site morbidities and geometric requirements. Tissue engineering technology has been able to recreate living bone grafts, but important challenges remain. Here, we will discuss a paradigm for engineering personalized bone grafts that comprises autologous cells, native bone scaffold, and a perfusion bioreactor culture system. As the bone regeneration outcome is dependent on the establishment of functional vasculature, we focus on emergent vascularization strategies. We propose that angiogenic events leading to vascularization can be recapitulated by harnessing the inflammatory responses. Finally, we discuss endochondral ossification as a strategy for engineering functional and well-vascularized bone that supports the engraftment of hematopoietic cells.
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1 citations in Scopus
Details
- Title
- Chapter 32 - Engineering Vascular Niche for Bone Tissue Regeneration
- Creators
- Johnathan Ng - Columbia UniversityKara Spiller - Drexel UniversityJonathan Bernhard - Columbia UniversityGordana Vunjak-Novakovic - Columbia University
- Publication Details
- Biology and Engineering of Stem Cell Niches, pp 517-529
- Publisher
- Elsevier
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Scopus ID
- 2-s2.0-85040553514
- Other Identifier
- 991019173952404721