Book chapter
Chapter 38 - ATP and its P2 receptors in pulmonary disorders
ATP, pp 837-846
2026
Abstract
Adenosine 5’-triphosphate (ATP) is found in every cell of the human body where it plays a critical role in cellular energetics and metabolism. ATP is released from multiple cell types under physiologic and pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine agent, the effects of which on targeted cells are mediated by cell-surface receptors, P2 purinergic receptors (P2Rs). Pathophysiologic conditions in the lungs are associated with elevated extracellular levels of ATP and the activation of several P2R subtypes, resulting in bronchoconstriction, cough, and proinflammatory effects. In 2002, this complex pathophysiologic mechanism was originally termed “ATP Axis in Chronic Obstructive Pulmonary Disorders.” Since then, numerous studies have validated this concept and outlined the details of the mechanistic roles that ATP plays in multiple pulmonary disorders, including asthma, COPD, and cough. This review is a succinct update of our knowledge in this field.
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Details
- Title
- Chapter 38 - ATP and its P2 receptors in pulmonary disorders
- Creators
- Amir PellegSir Peter Barnes - Imperial College LondonEdward S. Schulman - Drexel University
- Publication Details
- ATP, pp 837-846
- Publisher
- Elsevier Inc
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine); Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Other Identifier
- 991022163920704721