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Chapter 5 - Role of epigenetics in the brain
Book chapter

Chapter 5 - Role of epigenetics in the brain

Stephanie M. Matt, Eric D. Roth and Tania L. Roth
Epigenetics in Psychiatry, pp 85-109
2021

Abstract

Aging DNA methylation Imprinting Memory and stress Neural cell differentiation Neurogenesis Neuroimmune crosstalk Transgenerational inheritance
Epigenetic mechanisms play an important regulatory role in neural processes associated with brain development and phenotypic outcome, and do so from early embryonic development through senescence. Though a complete picture has yet to emerge, it is clear that epigenetic changes promote a range of processes important for brain evolution, development, and function. Herein, we highlight key studies demonstrating a role for epigenetic mechanisms in these phenomena, including changes in phenotypes that are passed on to the next generation, gene imprinting, neural cell differentiation, neurogenesis, neuroimmune crosstalk, cognition, and psychopathology.

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