Book chapter
Click Chemistry for Cyclic Peptide Drug Design
Methods in molecular biology (Clifton, N.J.), v 2001
01 Jan 2019
PMID: 31134571
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Click chemistry is a powerful tool in constraining peptides into their active conformations. This chapter presents recent advancements involving the use of copper-catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC), better known as "click reaction" in the design and synthesis of cyclic peptide and cyclic peptidomimetic compounds. The usage of "click chemistry" reactions includes various topics: (a) mimicking peptide bonds; (b) synthesis of ordered structures; (c) ligation of peptidomimetic scaffolds; and most importantly in this chapter (d) cyclization of peptidomimetic scaffolds using the triazole ring as constraint of conformation.
Metrics
Details
- Title
- Click Chemistry for Cyclic Peptide Drug Design
- Creators
- Adel Ahmed Rashad - Drexel University
- Publication Details
- Methods in molecular biology (Clifton, N.J.), v 2001
- Publisher
- Springer Nature
- Number of pages
- 13
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000487550500009
- Scopus ID
- 2-s2.0-85066251700
- Other Identifier
- 9781493995042; 1493995049; 991020172707904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Applied