Book chapter
Detecting Senescence: Methods and Approaches
Cell Cycle Control, pp 425-445
01 Jan 2014
PMID: 24906328
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The detection of senescent cells has become an important area of research in the aging field. Due to the complexity of the senescence program and the lack of a unique signature for senescence, the detection of these cells remains problematic. This is especially true for in vivo detection in aged or diseased tissue samples. This chapter outlines approaches for the detection of senescent cells based upon methods established for mesenchymal cells in culture. A stepwise approach to the detection of senescent cells using multiple techniques is provided.
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Details
- Title
- Detecting Senescence: Methods and Approaches
- Creators
- Elizabeth P. Crowe - Drexel UniversityTimothy Nacarelli - Drexel UniversityAlessandro Bitto - University of WashingtonChad Lerner - Lung Biology, and Disease Program, Pulmonary and Critical Care DivisionChristian Sell - Drexel UniversityClaudio Torres - Drexel University
- Contributors
- E Noguchi (Editor)M C Gadaleta (Editor)
- Publication Details
- Cell Cycle Control, pp 425-445
- Series
- Methods in Molecular Biology
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 21
- Grant note
- F30AG043307; R21 AG046943; AG039799 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01NS078283 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R21AG046943 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) 1R01NS078283 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Neurobiology and Anatomy; Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000338508500024
- Scopus ID
- 2-s2.0-84922481265
- Other Identifier
- 991019169815504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology