Book chapter
EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer
Molecular Determinants of Head and Neck Cancer, pp 55-90
01 Jan 2014
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Squamous cell carcinoma of the head and neck (SCCHN) is one of the more challenging cancers to treat. Although great progress has been made over the years, available treatment options are still far from ideal, as epitomized by a 5-year survival rate of only 30-40 %. A unique feature of SCCHN is that elevated expression of the epidermal growth factor receptor (EGFR), a member of the ErbB receptor tyrosine kinase (RTK) family and highly relevant to oncogenic proliferation, occurs in a significant number of cases, which has prompted great interest in utilizing EGFR-targeted therapies to treat this devastating disease. Significant advances in the treatment of SCCHN have been made using EGFR-targeting monoclonal antibodies. Another class of EGFR-targeting inhibitors, tyrosine kinase inhibitors (TKIs), has also shown promise as a potential treatment option. In order to appreciate how these therapeutic agents work and why they fail when they do, it is crucial to explore the biology of the ErbB family members, the signaling pathways that are associated with them, and how they interact with each specific therapeutic agent. This chapter discusses the biology of EGFR and other ErbB family members in SCCHN, and summarizes the current status of the application of EGFR and ErbB inhibitors.
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Details
- Title
- EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer
- Creators
- Hanqing Liu - Fox Chase Cancer CenterJennifer R. Cracchiolo - Temple UniversityTim N. Beck - Fox Chase Cancer CenterIlya G. Serebriiskii - Fox Chase Cancer CenterErica A. Golemis - Fox Chase Cancer Center
- Contributors
- B Burtness (Editor)E A Golemis (Editor) - Fox Chase Cancer Center
- Publication Details
- Molecular Determinants of Head and Neck Cancer, pp 55-90
- Series
- Current Cancer Research
- Publisher
- Springer Nature; NEW YORK
- Number of pages
- 36
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000337901600004
- Scopus ID
- 2-s2.0-84990979388
- Other Identifier
- 991019318932404721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology