Book chapter
Effects of Glycinergic Inhibition Failure on Respiratory Rhythm and Pattern Generation
Progress in Brain Research, pp 25-38
2014
PMID: 24746041
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inhibitory interactions between neurons of the respiratory network are involved in rhythm generation and pattern formation. Using a computational model of brainstem respiratory networks, we investigated the possible effects of suppressing glycinergic inhibition on the activity of different respiratory neuron types. Our study revealed that progressive suppression of glycinergic inhibition affected all neurons of the network and disturbed neural circuits involved in termination of inspiration. Causal was a dysfunction of postinspiratory inhibition targeting inspiratory neurons, which often led to irregular preterm reactivation of these neurons, producing double or multiple short-duration inspiratory bursts. An increasing blockade of glycinergic inhibition led to apneustic inspiratory activity. Similar disturbances of glycinergic inhibition also occur during hypoxia. A clear difference in prolonged hypoxia, however, is that the rhythm terminates in expiratory apnea. The critical function of glycinergic inhibition for normal respiratory rhythm generation and the consequences of its reduction, including in pathological conditions, are discussed.
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Details
- Title
- Effects of Glycinergic Inhibition Failure on Respiratory Rhythm and Pattern Generation
- Creators
- Natalia A Shevtsova - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USADietrich Büsselberg - Weill Cornell Medical College in Qatar, Education City, Doha, QatarYaroslav I Molkov - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USAAnne M Bischoff - Department of Neuro- and Sensory Physiology, University of Göttingen, Göttingen, GermanyJeffrey C Smith - Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USADiethelm W Richter - Department of Neuro- and Sensory Physiology, University of Göttingen, Göttingen, GermanyIlya A Rybak - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
- Publication Details
- Progress in Brain Research, pp 25-38
- Publisher
- Elsevier Science & Technology
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000349323900003
- Scopus ID
- 2-s2.0-84927170654
- Other Identifier
- 991014877776604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Physiology