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Enhancement of adult dorsal root regeneration by embryonic spinal cord transplants
Book chapter   Peer reviewed

Enhancement of adult dorsal root regeneration by embryonic spinal cord transplants

A Tessler, B T Himes, C Rogahn, J Houle and P J Reier
Progress in brain research, v 78(C), pp 213-218
01 Jan 1988
DOI: https://doi.org/10.1016/S0079-6123(08)60286-1
PMID: 3266800
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Regeneration appears to depend on an interaction between the injured axon's intrinsic capacity to regrow and the environment in which the regrowth must occur. This chapter describes and shows that regeneration occurs and that calcitonin gene-related peptide (CGRP)-containing axons are among those that regenerate. Exposed to the same type of graft, populations of neurons differ in their regenerative capacity, suggesting that some central neurons may be extremely limited in their ability to regrow or that the conditions necessary to elicit their growth are not provided by the usual grafts. The dorsal root ganglion (DRG) neurons are classified into subgroups based on criteria, such as size and immunocytochemical staining characteristics, and may differ in their capacity to regenerate, or in the vigor of their response to the conducive environment, or the stimulation provided by a transplant. The chapter shows using a marker specific for a population of small- and medium-sized DRG neurons that dorsal root cells immunoreactive for CGRP are among those, which regenerate into transplants.

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Domestic collaboration
Web of Science research areas
Neurosciences
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