Book chapter
Evaluating Stress Granules in Pancreatic Cancer In Vitro and In Vivo: Methods and Protocols
Pancreatic Cancer, pp 183-195
01 Jan 2019
PMID: 30378055
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Stress granules are nonmembranous organelles that function as a stress-adaptation mechanism. We have recently shown that stress granules are mobilized by mutant KRAS pancreatic cancer cells under stress to enhance tumor fitness and survival. In this chapter, we outline a method for inducing, detecting, and quantifying stress granules in pancreatic cancer cells in vitro and in vivo. This method can be utilized to better understand the mechanisms driving stress granule formation and their role in pancreatic tumorigenesis.
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Details
- Title
- Evaluating Stress Granules in Pancreatic Cancer In Vitro and In Vivo
- Creators
- Edward Sim - Thomas Jefferson UniversityElena Irollo - Thomas Jefferson UniversityElda Grabocka - Thomas Jefferson University
- Contributors
- G H Su (Editor)
- Publication Details
- Pancreatic Cancer, pp 183-195
- Series
- Methods in Molecular Biology
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 13
- Grant note
- R37 CA230645 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000683074400018
- Scopus ID
- 2-s2.0-85055650367
- Other Identifier
- 991021901315404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Oncology