Book chapter
Exercise as a therapeutic intervention for neuropathic pain after spinal cord injury
Spinal Cord Injury Pain, pp 443-463
2022
Abstract
After spinal cord injury (SCI) there is a progressive cascade of events that greatly effects the health and well-being of the injured subject, beyond the devastating loss of intentional movement. Exercise or physical training has a demonstrated role in the relearning of motor tasks and there is gathering evidence that some secondary consequences of SCI, such as autonomic dysreflexia, muscle spasticity, and chronic inflammation, respond to exercise as a treatment strategy. We have extended these findings by examining the effects of exercise on molecular and cellular components of the injured spinal cord and dorsal root ganglia to begin to understand how exercise might be useful in preventing and/or alleviating the devastating neuropathic pain that develops in the majority of SCI individuals. We briefly discuss ways in which exercise can bring about neuroprotection, neuroplasticity, and axon regeneration that we feel provide clues about why different forms of exercise are proving to be effective in modulating pain in acute and chronic injury models.
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Details
- Title
- Exercise as a therapeutic intervention for neuropathic pain after spinal cord injury
- Creators
- John D. HouleMegan R. Detloff
- Publication Details
- Spinal Cord Injury Pain, pp 443-463
- Publisher
- Elsevier
- Number of pages
- 21
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-85139301796
- Other Identifier
- 991019173946804721