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Expression of MHC Class I Genes in Mouse Hepatitis Virus (MHV-A59) Infection and in Multiple Sclerosis
Book chapter   Open access   Peer reviewed

Expression of MHC Class I Genes in Mouse Hepatitis Virus (MHV-A59) Infection and in Multiple Sclerosis

Ehud Lavi, Akio Suzumura, Lois A. Lampson, Richard M. Siegel, Donna M. Murasko, Donald H. Silberberg and Susan R. Weiss
Coronaviruses, pp 219-222
1987
DOI: https://doi.org/10.1007/978-1-4684-1280-2_26
PMID: 2829530
url
https://doi.org/10.1007/978-1-4684-1280-2_26View
Published, Version of Record (VoR) Open

Abstract

Major Histocompatibility Complex Major Histocompatibility Complex Antigen Major Histocompatibility Complex Class Mouse Hepatitis Virus Multiple Sclerosis
The alteration in expression of major histocompatibility complex (MHC) class I genes on neural cells in association with central nervous system (CNS) demyelination was studied. Infection of mice or glial cell cultures with a neurotropic demyelinating coronavirus, mouse hepatitis virus (MHV) strain A59, was used as a model system. While uninfected neural cells do not express detectable amounts of MHC class I surface antigens, after infection with MHV-A59 in vitro or in vivo, these antigens can be detected by reaction with a monoclonal antibody against H-2D and H-2K. Induction of MHC class I antigens by MHV-A59 infection in mice was associated with increased levels of H-2 mRNA. Upregulation of MHC class I antigens involved the production of soluble factor/s produced by infected astrocytes. The identity of the factor, which is not interferon, is at present unknown. Brain specimens from autopsies of patients with multiple sclerosis, a human inflammatory demyelinating diseases, were also examined for alteration of MHC antigens. Both class I and class II surface antigens were found in active plaques but not in chronic plaques or in normal brain. These results are consistent with the hypothesis that MHC class I antigen induction may play a role in inflammatory CNS demyelination in both experimental animals and in humans.

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