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Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior
Book chapter

Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior

Philip J. Clark and Rodrigo A. España
Dopaminergic System Function and Dysfunction: Experimental Approaches
08 Dec 2022

Abstract

Addiction Catecholamines Cocaine Electrochemistry Neurochemistry Neurotransmission
Electrochemical techniques have allowed investigators to measure analytes of interest for decades. Of these techniques, fast scan cyclic voltammetry (FSCV) offers advantages that make it ideal for applications in neuroscience research. FSCV is particularly valuable due to its high temporal resolution and specificity for analytes such as dopamine (DA), serotonin, and norepinephrine. Finally, the development of FSCV for use in anesthetized, ex vivo, and freely moving preparations has broadened experimental options—allowing investigators to measure DA across a wide range of contexts. In this chapter, we describe FSCV, its principles and methodologies, popular implementations, and provide examples of discoveries made with this powerful technique.

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