Book chapter
Glutamine Metabolism and Cancer
Encyclopedia of Cancer, pp 179-186
2019
Abstract
Cancer cells consume large amount of glutamine which greatly exceeds the needs for direct use for protein translation and nucleotide synthesis. Independent studies have demonstrated that glutaminolysis driven by oncogenic signaling pathways accounts for this increased consumption. This article summarizes the direct and indirect metabolic roles of glutamine in cancer cell metabolism. In addition, we will discuss how oncogenic signaling pathways regulate glutamine utilization in cancers, and how cancer cells respond to glutamine depletion.
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Details
- Title
- Glutamine Metabolism and Cancer
- Creators
- Nianli Sang - Drexel University, Philadelphia, PA, United StatesDan He - Drexel University, Philadelphia, PA, United StatesShuo Qie - Medical University of South Carolina, Charleston, SC, United States
- Publication Details
- Encyclopedia of Cancer, pp 179-186
- Publisher
- Elsevier
- Edition
- Third Edition
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Biology
- Scopus ID
- 2-s2.0-105000728825
- Other Identifier
- 991019173563004721