Book chapter
Hepatitis C Virus Infection: A New Era
Contemporary Liver Transplantation, pp 247-254
01 Jan 2017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rapid and dramatic advances in development of the modern generation of direct antiviral agents specific for hepatitis C have occurred over the last 3 years. In this chapter, we discuss the applications of the new antiviral agents to patients with hepatitis C infection relevant to liver transplantation, namely, those with compensated and decompensated cirrhosis, patients with hepatocellular carcinoma (HCC) related to HCV, and in liver transplant recipients with recurrent HCV. The limits of applicability of the new direct antiviral agents (DAAs) are reviewed, as well as the new issues raised by the high rates of HCV cure. The global impact of high cure rates of HCV has not yet been fully appreciated. Access to the new antiviral agents and diagnosing the large numbers of patients currently unaware of this infection are clearly now the major challenges, rather than discovering new agents to optimizing cure rates. Liver transplantation for HCV and HCV-related HCC is likely to remain at current levels for the rest of the decade, but recipients and allografts are likely to enjoy a much longer useful life following HCV eradication with DAAs.
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Details
- Title
- Hepatitis C Virus Infection: A New Era
- Creators
- Santiago J. Munoz - Drexel Coll Med, Hahnemann Univ Hosp, Div Gastroenterol & Hepatol, Dept Med,Liver Transplant Program, Philadelphia, PA 19129 USAKenneth D. Rothstein - Drexel Coll Med, Hahnemann Univ Hosp, Div Gastroenterol & Hepatol, Dept Med,Liver Transplant Program, Philadelphia, PA 19129 USAAlexandra L. Gibas - Reg Gastroenterol Associates Lancaster, Lancaster, PA USA
- Contributors
- C Doria (Editor)
- Publication Details
- Contemporary Liver Transplantation, pp 247-254
- Series
- Organ and Tissue Transplantation
- Publisher
- Springer Nature; CHAM
- Number of pages
- 8
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000487753100015
- Other Identifier
- 991019167931204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology
- Transplantation