Book chapter
Human Immunodeficiency Virus Viral Protein R as an Extracellular Protein in Neuropathogenesis
Advances in Virus Research, pp 165-199
2011
PMID: 22094081
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Numerous studies published in the past two decades have identified the viral protein R (Vpr) as one of the most versatile proteins in the life cycle of human immunodeficiency virus type 1 (HIV-1). In this regard, more than a thousand Vpr molecules are present in extracellular viral particles. Subsequent to viral entry, Vpr participates in early replicative events by assisting in viral genome nuclear import and, during the viral life cycle, by shuttling between the nucleus and the cytoplasm to accomplish its functions within the context of other replicative functions. Additionally, several studies have implicated Vpr as a proapoptotic protein because it promotes formation of permeability transition pores in mitochondria, which in turn affects transmembrane potential and adenosine triphosphate synthesis. Recent studies have identified Vpr as a virion-free protein in the serum and cerebrospinal fluid of patients infected with HIV-1 whose plasma viremia directly correlates with the extracellular concentration of Vpr. These observations pointed to a new role for Vpr as an additional weapon in the HIV-1 arsenal, involving the use of an extracellular protein to target and possibly inhibit HIV-1-uninfected bystander cells to enable them to escape immune surveillance. In addition, extracellular Vpr decreases adenosine triphosphate levels and affects the intracellular redox balance in neurons, ultimately causing their apoptosis. Herein, we review the role of Vpr as an extracellular protein and its downstream effects on cellular metabolism, functionality, and survival, with particular emphasis on how extracellular Vpr-induced oxidative stress might aggravate HIV-1-induced symptoms, thus affecting pathogenesis and disease progression.
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Details
- Title
- Human Immunodeficiency Virus Viral Protein R as an Extracellular Protein in Neuropathogenesis
- Creators
- Adriano Ferrucci - School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USAMichael R Nonnemacher - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USABrian Wigdahl - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
- Publication Details
- Advances in Virus Research, pp 165-199
- Publisher
- Elsevier Science & Technology
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000299435300005
- Scopus ID
- 2-s2.0-81155151443
- Other Identifier
- 991014878120104721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Virology