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Hypocretin/Orexin Involvement in Reward and Reinforcement
Book chapter   Open access   Peer reviewed

Hypocretin/Orexin Involvement in Reward and Reinforcement

Rodrigo A. España
Vitamins and Hormones, pp 185-208
2012
PMID: 22640614
url
https://europepmc.org/articles/pmc4712645View
Accepted (AM)Open Access (License Unspecified) Open

Abstract

Addiction Cocaine Conditioned place preference Dopamine Hypocretin Microdialysis Nucleus accumbens Orexin Self-administration Voltammetry
Since the discovery of the hypocretins/orexins, a series of observations have indicated that these peptides influence a variety of physiological processes including feeding, sleep/wake function, memory, and stress. More recently, the hypocretins have been implicated in reinforcement and reward-related processes via actions on the mesolimbic dopamine system. Although investigation into the relationship between the hypocretins and reinforcement/reward remains in relatively early stages, accumulating evidence suggests that continued research into this area may offer new insights into the addiction process and provide the foundation to generate novel pharmacotherapies for drug abuse. The current chapter will focus on contemporary perspectives of hypocretin regulation of cocaine reward and reinforcement via actions on the mesolimbic dopamine system.

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23 citations in Scopus

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Web of Science research areas
Biochemistry & Molecular Biology
Endocrinology & Metabolism
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