Book chapter
Hypocretin/Orexin Involvement in Reward and Reinforcement
Vitamins and Hormones, pp.185-208
Elsevier Science & Technology
2012
PMCID: PMC4712645
PMID: 22640614
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Since the discovery of the hypocretins/orexins, a series of observations have indicated that these peptides influence a variety of physiological processes including feeding, sleep/wake function, memory, and stress. More recently, the hypocretins have been implicated in reinforcement and reward-related processes via actions on the mesolimbic dopamine system. Although investigation into the relationship between the hypocretins and reinforcement/reward remains in relatively early stages, accumulating evidence suggests that continued research into this area may offer new insights into the addiction process and provide the foundation to generate novel pharmacotherapies for drug abuse. The current chapter will focus on contemporary perspectives of hypocretin regulation of cocaine reward and reinforcement via actions on the mesolimbic dopamine system.
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Details
- Title
- Hypocretin/Orexin Involvement in Reward and Reinforcement
- Creators
- Rodrigo A. España - Drexel University
- Publication Details
- Vitamins and Hormones, pp.185-208
- Publisher
- Elsevier Science & Technology
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991019168109204721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism