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Iminosugars as Antiviral Agents
Book chapter

Iminosugars as Antiviral Agents

Pamela A Norton, Baohua Gu and Timothy M Block
Iminosugars, pp 209-224
05 Oct 2007

Abstract

alkylated iminosugar molecules calnexin sensitive site glucosidase inhibition and antiviral action glucosidase inhibition specificity glucosidase inhibitor treatment influenza virus haemaglutinin intracellular glycoprotein retention sequentially active glycoprocessing enzymes viral glycoproteins and virion‐associated DNA reduced secretion viral glycoproteins maturation
This chapter contains sections titled: Introduction The relationship between glucosidase inhibition and antiviral action Fate of viral glycoproteins in glucosidase‐inhibited cells Specificity of glucosidase inhibition N‐Alkyl DNJs inhibit virus growth by non‐glucosidase inhibitory mechanisms – other potential activities of these compounds New directions for improving glucosidase inhibitors as antiviral agents References

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