Book chapter
Immunology in Plasma Cancer Treatment
Plasma Cancer Therapy, pp 209-222
19 Aug 2020
Abstract
Cancer is a devastating and life-threatening disease. For decades, the emphasis of investigations into therapeutic modalities has focused on drug development and delivery. However, it soon became evident that the direct killing of cancer cells via anticancer therapies is only one side of the coin. The other side is the notion that the immune system can recognize and eliminate tumors in a highly specific manner. Nevertheless, cancer patients’ immunity often needs help in doing so, leading to the creation of checkpoint antibody-based immunotherapies. These were awarded the Nobel Prize for Medicine or Physiology in 2018 and have set the stage for a multifaceted view of methods to promote anticancer immunity. Among the novel tools to do so are medical gas plasma devices and treatment regimens. While in principle gentle to the tissue with no necrotic or thermal harm being imposed, this reactive oxygen species-triggered tumor cell death was recently shown to have pro-immunogenic properties. The latest results and findings in this field are the subject of this book chapter along with a brief lay-reader-explanation of cancer and immunology.
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1 citations in Scopus
Details
- Title
- Immunology in Plasma Cancer Treatment
- Creators
- Sander Bekeschus - Leibniz Institute for Plasma Science and TechnologyGeorg Bauer - University Medical Center FreiburgVandana Miller - Drexel University
- Publication Details
- Plasma Cancer Therapy, pp 209-222
- Series
- Springer Series on Atomic, Optical, and Plasma Physics
- Publisher
- Springer International Publishing; Cham
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Microbiology and Immunology; Microbiology Department Internal Research
- Scopus ID
- 2-s2.0-85104641723
- Other Identifier
- 991021463687204721