Book chapter
In Vitro Model of Macrophage-Biomaterial Interactions
Biomaterials for Tissue Engineering
21 Apr 2018
PMID: 29679330
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tissue engineering and regenerative medicine, facilitated by biomaterial-based therapies, hold promise for the repair, replacement, or regeneration of damaged tissue. The success or failure of all implanted biomaterials, ranging from stainless steel total joint replacements to naturally or synthetically derived skin grafts, is predominantly mediated by macrophages, the primary cell of the innate immune system. In an effort to better assess safety and efficacy of novel biomaterials, evaluating and understanding macrophage-biomaterial interactions is a necessary first step. Here, we describe the culture of macrophages on 3D biomaterials, such as decellularized human cortical bone or commercially available wound matrices, and subsequent analysis using gene expression and protein secretion to help understand how biomaterial properties may influence macrophage phenotype in vitro.
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Details
- Title
- In Vitro Model of Macrophage-Biomaterial Interactions
- Creators
- Claire E. Witherel - Drexel UniversityPamela L. Graney - Drexel UniversityKara L. Spiller - Drexel University
- Publication Details
- Biomaterials for Tissue Engineering
- Series
- Methods in Molecular Biology
- Publisher
- Springer New York; New York, NY
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000441300200014
- Scopus ID
- 2-s2.0-85045877281
- Other Identifier
- 991019168901204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cell & Tissue Engineering
- Cell Biology