Book chapter
In vivo neuroprotection of injured CNS neurons by a single injection of a DNA plasmid encoding the Bcl-2 gene
Progress in Brain Research, pp 365-372
2000
PMID: 11105694
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury is a devastating event for which there is no effective treatment or cure. Axons that descend to the spinal cord from neurons located in the brain and axons that ascend from the spinal cord to higher centers of the nervous system are severed or otherwise damaged. Many of these neurons are lost by retrograde death, an apoptotic process, and those that survive are not able to regenerate their axons to their normal targets. Additional cells are lost at the injury site as the lesion expands during the days and weeks following injury (bystander death). The goals of therapeutic approaches to spinal cord injury should include rescue of neurons otherwise destined to die, which could increase the population of neurons available for axon regeneration and permit the reestablishment of functional cell to cell interactions with suitable targets. Previous studies have shown that supplying trophic factors prevented loss of neurons that express the cell surface receptors for those factors. This chapter describes recent experiments designed to rescue injured neurons in animal models of central nervous system (CNS) mechanical and chemical injuries by delivering a DNA plasmid that codes for the antiapoptotic B-cell lymphoma 2 (Bcl-2) gene. The product of this gene acts downstream of trophic factors and prevents activation of the late stages of apoptosis. This method, therefore, could be an effective means to rescue
different populations of neurons.
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Details
- Title
- In vivo neuroprotection of injured CNS neurons by a single injection of a DNA plasmid encoding the Bcl-2 gene
- Creators
- Raul A. Saavedra - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)Marion Murray - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)Sonsoles de Lacalle - California State University Los AngelesAlan Tessler - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Publication Details
- Progress in Brain Research, pp 365-372
- Publisher
- Elsevier Science & Technology
- Number of pages
- 8
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000169388600031
- Scopus ID
- 2-s2.0-0034589391
- Other Identifier
- 991019168268004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences