Book chapter
Infections of the Central Nervous System
Pathy's Principles and Practice of Geriatric Medicine, pp 1447-1463
13 Apr 2012
Abstract
Central nervous system infections are frequently devastating and can lead to significant morbidity and mortality. Although the brain possesses several defence mechanisms (e.g. intact cranium, blood–brain barrier) to prevent infection, once microorganisms reach the central nervous system, host defence mechanisms are inadequate to control the infection. Antimicrobial therapy is also limited by the poor penetration of many agents into the central nervous system. This chapter reviews meningitis, brain abscess, subdural empyema, epidural abscess, encephalitis, postpolio syndrome and Creutzfeldt–Jakob disease, stressing recent developments in diagnosis and therapy and the use of adjunctive treatment strategies that have been shown to improve outcome in patients with some of these devastating infections.
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26 citations in Scopus
Details
- Title
- Infections of the Central Nervous System
- Creators
- Michael Blank - Firelands Regional Medical CenterAllan R Tunkel - Drexel University
- Contributors
- Alan J Sinclair (Editor) - Institute of Diabetes for Older People (IDOP), Luton, UKJohn E Morley (Editor) - Saint Louis University School of Medicine and St Louis Veterans' Affairs Medical Center, St Louis, MO, USABruno Vellas (Editor) - Université de Toulouse
- Publication Details
- Pathy's Principles and Practice of Geriatric Medicine, pp 1447-1463
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 17
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Scopus ID
- 2-s2.0-84886208012
- Other Identifier
- 991019346717804721