Book chapter
Inhibition of T Cell Cytotoxicity by Cyclosporine (CSA), Adenosine (ADO) and an Inhibitor of Adenosine Deaminase (ADA)
Purine and Pyrimidine Metabolism in Man V
1986
PMID: 3490123
Abstract
Cyclosporine (CSA-previously known as cyclosporin A) is the prototype of a new class of polypeptide lipophilic immunosuppressive agents with cell membrane affinity.1,2 The predominant immunosuppressive effects of this compound in vivo seem to result from depressed helper T cell function. In vitro studies indicate that CSA inhibits proliferation of alloreactive cells in mixed lymphocyte culture and the generation of alloreactive cytolytic lymphocytes (CTL).4 As shown by Orosz et al,5 this inhibition of clonal expansion relates specifically to the alloantigen driven response of both helper and CTL. However, from current reports CSA does not appear effective against antigen-directed cytotoxic cells already committed to that function. 5,6
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Details
- Title
- Inhibition of T Cell Cytotoxicity by Cyclosporine (CSA), Adenosine (ADO) and an Inhibitor of Adenosine Deaminase (ADA)
- Creators
- Caliann T. Lum - The University of Texas Health Science Center at San AntonioStephen R. Jennings - The University of Texas Health Science Center at San AntonioFrederick J. Wanner - The University of Texas Health Science Center at San AntonioSatvir S. Tevethia - The University of Texas Health Science Center at San Antonio
- Publication Details
- Purine and Pyrimidine Metabolism in Man V
- Series
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US; New York, NY
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Scopus ID
- 2-s2.0-0022438812
- Other Identifier
- 991020545121904721