Book chapter
Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells
Cell Cycle Control, pp 41-59
01 Jan 2014
PMID: 24906308
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The cell cycle is intimately associated with the ability of cells to sense and respond to and repair DNA damage. Understanding how cell cycle progression, particularly DNA replication and cell division, are regulated and how DNA damage can affect these processes has been the subject of intense research. Recent evidence suggests that the repair of DNA damage is regulated by the cell cycle, and that cell cycle factors are closely associated with repair factors and participate in cellular decisions regarding how to respond to and repair damage. Precise regulation of cell cycle progression in the presence of DNA damage is essential to maintain genomic stability and avoid the accumulation of chromosomal aberrations that can promote tumor formation. In this review, we discuss the current understanding of how mammalian cells induce cell cycle checkpoints in response to DNA double-strand breaks. In addition, we discuss how cell cycle factors modulate DNA repair pathways to facilitate proper repair of DNA lesions.
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Details
- Title
- Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells
- Creators
- Kate Beishline - Drexel UniversityJane Azizkhan-Clifford - Drexel University
- Contributors
- E Noguchi (Editor)M C Gadaleta (Editor)
- Publication Details
- Cell Cycle Control, pp 41-59
- Series
- Methods in Molecular Biology
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 19
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; [Retired Faculty]
- Web of Science ID
- WOS:000338508500004
- Scopus ID
- 2-s2.0-84922481916
- Other Identifier
- 991019168304704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology