Book chapter
Intracellular Pressure: A Driver of Cell Morphology and Movement
International Review of Cell and Molecular Biology, pp 185-211
01 Jan 2018
PMID: 29551161
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intracellular pressure, generated by actomyosin contractility and the directional flow of water across the plasma membrane, can rapidly reprogram cell shape and behavior. Recent work demonstrates that cells can generate intracellular pressure with a range spanning at least two orders of magnitude; significantly, pressure is implicated as an important regulator of cell dynamics, such as cell division and migration. Changes to intracellular pressure can dictate the mechanisms by which single human cells move through three-dimensional environments. In this review, we chronicle the classic as well as recent evidence demonstrating how intracellular pressure is generated and maintained in metazoan cells. Furthermore, we highlight how this potentially ubiquitous physical characteristic is emerging as an important driver of cell morphology and behavior.
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Details
- Title
- Intracellular Pressure: A Driver of Cell Morphology and Movement
- Creators
- Pragati Chengappa - Drexel UniversityKimheak Sao - Drexel UniversityTia M. Jones - Drexel UniversityRyan J. Petrie - Drexel University
- Contributors
- L Galluzzi (Editor)
- Publication Details
- International Review of Cell and Molecular Biology, pp 185-211
- Series
- International Review of Cell and Molecular Biology
- Publisher
- Elsevier; SAN DIEGO
- Number of pages
- 27
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000435932100007
- Scopus ID
- 2-s2.0-85041566680
- Other Identifier
- 991019167626004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology